Van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender emerged as the first backline player to net two goals in a Premier League match for Spurs since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods home two times in opening period
Everton's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr scores final goal in dying moments
The defeat is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven found the net twice as Tottenham prolonged their unbeaten run in away games in the Premier League and delivered Everton their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at the dockside location, having departed their historic home behind after more than a century at the end of last season.
But Tottenham's leader Van de Ven pounced twice from corners in the first half to put their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had equalized the scores a short while after the defender's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a handful of chances, while the Italian goalkeeper made a series of fine stops to ensure Tottenham went five away games without defeat in the English top flight.
But the VAR intervened, instructing the match official to check the goal on the pitchside monitor and the referee decided that the winger and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's team up to third in the Premier League, a handful of points off north London rivals and leaders the Gunners.
The Merseyside club remain 14th and sit half a dozen points ahead of the relegation zone.
Tottenham analysis: The defender fulfils role at both ends of pitch
After a drab weekday performance in the European competition against Monaco, where they mustered a mere two shots on goal, Frank opted for Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was failed to make much of an impact before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an offensive threat to be feared.
Tottenham's first goal came from a well-worked corner routine, with the midfielder directing the ball toward the face of goal for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as skipper in Cristian Romero's absence - added his second in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was just as impressive in defence, combining well with his defensive colleague as the pair handled excellently with the 34 crosses thrown their way by Everton.
Everton analysis: Everton missing striker's instinct
Everton's new home had been a fortress, but it appears the novelty may have faded slightly and supporters flocked to the exits after Sarr's third for Tottenham.
The end in Everton's unbeaten home run won't be a massive worry for David Moyes, but their attacking woes are.
The forward and Thierno Barry - the Everton's pair of established centre-forwards - had netted just one league goal combined before Sunday's outing.
And they were unable to contribute to that miserable record on a damp and dreary evening on Merseyside.
Beto's performance was epitomized when he opted to bicycle-kick a clear chance from near the goal, even with having space and time to reposition for a more conventional shot that would have challenged Vicario.
Barry, too, failed to make an impact after replacing the starter in the 65th minute.
It wasn't for a shortage of chance. Most of the home side's offensive moves came through the winger and the forward, who relentlessly delivered dangerous balls into the Spurs box.
What next for both teams?
The Toffees: The team travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs go to Newcastle's ground on late October for their fourth-round League Cup tie against Newcastle.